Glucosamine, 2-amino-2-deoxy-D-glucose, is an amino monosaccharide that is an essential component of mucopolysaccharides and chitin. Glycosaminoglycans (mucopolysaccharides) are large complexes of negatively-charged carbohydrate chains that are incorporated into mucous secretions, connective tissue, skin, tendons, ligaments and cartilage. Glucosamine and its acetylated derivative, N-acetylglucosamine, are readily synthesized in the body from glucose. Because of its high concentration in joint tissues, the hypothesis that glucosamine supplements would provide symptomatic relief for osteoarthritis was developed more than 30 years ago (D’Ambrosio et al., 1981). Many clinical trials have tested this hypothesis (Institute of Medicine, 2004) and glucosamine supplements are widely used to relieve arthritic complaints (Houpt et al., 1999).
To meet the demand for glucosamine nutritional supplements, three forms of glucosamine are commonly available: glucosamine hydrochloride, glucosamine sulfate, and N-acetyl-glucosamine. These glucosamine compounds are generally derived from chitin, a biopolymer present in the exoskeleton of marine invertebrate animals. The glucosamine derived from chitin in the cell walls of many fungi appears to be chemically identical to that found in marine invertebrates (Institute of Medicine, 2004).