Atherosclerosis is a disease of the large- and medium-sized arteries i.e. coronary artery, carotid artery, arteries of the lower extremities, and large elastic arteries including thoracic and abdominal aortae (Abdelhalim et al., 1994; Ross, 1993; Sato and Ohshima, 1992; Shankar and Bond, 1990; Stary, 1989). Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel (Howard et al., 2002). Hypercholesterolemia is considered a major risk factor in the development of atherosclerotic disease (Fidan et al., 2006; Sandra, 2006).
Presently, increasing numbers of the adult and geriatric populations are developing this disease. The effects of cholesterol feeding periods on the mechanical properties of excised thoracic and abdominal aortae of rabbits fed a diet containing high levels of cholesterol and saturated fat have been investigated by means of a tensile testing machine (Abdelhalim et al., 1993, 1994; Cox, 1979; Hayashi et al., 1987; Hudetz et al., 1981; Richter and Mittermayer, 1984; Sato and Ohshima, 1992; Shankar and Bond, 1990; Miyazaki et al., 1983). These studies demonstrated significant changes in the mechanical properties of aortae during the development of atherosclerosis. High fat diet-induced prothrombotic state, endothelial dysfunction precedes both the morphologically detectable lesions and the enhancement of platelet reactivity (Rumiko et al., 2006).