Coronary heart disease (CHD) is a significant cause of morbidity and mortality in Australia, New Zealand and many affluent and developing countries. It is a much-studied subject with a voluminous body of literature describing the disease process, the genetic and environmental factors involved in increasing and decreasing risk and the routes to prevention and treatment. Coronary events are the key outcomes of the condition and include myocardial infarction (MI), ischaemia and (sudden) cardiac death as the major outcomes for the disease. Atherosclerosis is the underlying process for CHD and involves the occlusion of the coronary arteries through the accumulation of lipids in the intima. Ischaemia results from a loss of tissue perfusion leading to inadequate oxygenation and nutrient supply.
MI is a major loss of blood flow resulting from arterial occlusion while sudden cardiac death can result from instability of cardiac contraction (arrhythmia). CHD has a complex multifactorial aetiology and there is an inherited element in risk (e.g. apolipoprotein phenotype) and also those which cannot be changed (e.g. age). There is also a strong modifiable component including lifestyle factors. Factors which contribute to increased risk include high blood pressure (hypertension), obesity, diabetes, cigarette smoking and lack of exercise. Obesity (especially abdominal obesity) is an independent risk factor but also predisposes to diabetes, another independent risk factor. However, there is an interaction between these two and hypertension leading to the so-called “metabolic syndrome” which predisposes to early-onset CHD.