I would like to introduce this collection of papers with a tribute to Sir Richard Doll, who died in 2005 at the grand old age of 92. Julian Peto and I went to talk to him about vitamin D while he was still fit and well.
Doll had shown that a four-monthly oral doseof 100,000 IUs vitamin D3 reduced fractures in people over 65 [1]. The study, undertaken with Daksha Trivedi and Kay Tee Khaw, also showed a non-significant reduction in mortality in the subjects who took vitamin D. Impressed by these results, and believing that vitamin D probably had beneficial effects other than those on bone, Doll himself took a monthly vitamin D tablet equivalent to about 1,000 IUs per day. In fact the tablet he was taking was vitamin D2, which only has one-third the potency of D3. High-dose vitamin D preparations are only available on prescription in the UK and are all formulated with D2. Most clinicians are not aware of the important difference in potency between D2 and D3.