A common public misconception is that substances are safe if they are natural, whereas they are likely to be hazardous if they are synthetically produced. We present evidence against this misconception. The idea that “natural is safe” may account in part for public concern about synthetic pesticide residues in the diet vs. public interest in and consumption of medicinal herbs.
Dietary supplements, such as medicinal herbs, receive little regulatory scrutiny or limits compared to synthetic chemicals such as pesticide residues or pharmaceuticals, even though every chemical is toxic at some dose. Under the Dietary Supplement Health and Education Act (DSHEA) of 1994, dietary supplements may be sold without approval by FDA, and there are no standards for specific toxicological testing; this contrasts sharply with drugs, for which evidence of efficacy and safety must be presented to FDA prior to sale. We indicate in this statement that: Gaining a broad perspective about the vast number of chemicals to which humans are exposed is important when setting research and regulatory priorities, and should include comparisons between ordinary exposure levels and the toxic dose level of a given chemical.