Cardiovascular disease (CVD) and stroke (cerebrovascular disease) are among the top three leading causes of death in OECD countries (OECD 2001). Cardiovascular disease, cancer and stroke rank number one through three respectively. These diseases have significant economic implications from a health policy perspective. The most cost effective approach in the long run is prevention which will require adjustments in health related behaviour. In the short run, at least, the health care system will continue to be responsible for management of CVD and stroke through medical interventions.
These interventions include surgery, rehabilitation, and pharmacotherapy, of which the latter is the most frequently used. Pharmacotherapy is used to ameliorate a variety of CVD and stroke risk factors, to provide symptomatic relief, to offer maintenance care, and to directly address the causes of disease. For CVD and stroke, drug therapy is the mainstay of maintenance care and a significant component of medical strategies designed to prevent acute events. Once CVD and stroke patients begin drug therapy it continues for the remainder of their lives. Thus, pharmacotherapy has the potential for significant clinical, economic, and humanistic impact which is likely to increase in importance as the population in OECD countries becomes more elderly.