Ebook The Necessity of Diet Therapy for Successful Interferon- y Therapy in Atopic Dermatitis
Atopic dermatitis (AD) is a skin disease due to immune dysregulation, although the role of allergy is controversial in the disease. The conventional treatments for AD comprise the use of emollients, steroids, sedating antihistamines at night, antibiotics, and the avoidance of irritating detergents or clothing. However, with even the most devoted applications of these measures, a number of patients still suffer from this persistent and troublesome disease. Immunosuppressive drugs such as cyclosprorin A, and immunomodulatory therapy of interferon (IFN)-/, IFN-a, thymopentin, and intravenous immunoglobulin (IVIG) have been tried. IFN- / therapy in AD has been tried with limited success.
There have been frequent symptomatic fluctuations during therapy and rapid recurrences after therapy.9 Therefore, the use of INF-/ therapy has waned due unsatisfactory clinical results such as a low response rate, a high recurrence rate, frequent symptomatic fluctuations, high cost, and considerable time consumption.
Although there is no consensus concerning the role of food allergy in the etiology of AD, it has been demonstrated that food hypersensitivity played a pathogenic role in a significant number of children who had AD. The appropriate identification of food hypersensitivity and subsequent exclusion diets can lead to significant improvements. To address this controversy, the clinical effects of an elimination diet in AD were evaluated in the first step of this study. In the second step, the therapeutic effects of an elimination diet in IFN- / therapy of AD were investigated. Some investigators have suggested the supply of an elemental diet as an initial dietary manipulation in AD. While others have suggested an elimination diet. In this study, the process of the elimination diet was modified for the convenience and compliance of patients.
The effectiveness of these elimination diet processes was verified. A properly performed double-blind, placebo-controlled food challenge (DBPCFC) has been shown to be the only accepted test for the confirmation of the diagnosis of adverse reactions to food. However, the validity of an open food challenge test has proven to be convincing for the food challenge method. Additionally, the usefulness of a careful history taking of food allergy, skin prick test, and specific IgE detection have been statistically described by comparing open food challenge test results.
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