Download Free ebooks PDF PARP INHIBITION SENSITIZES P53-DEFICIENT BREAST CANCER CELLS TO DOXORUBICIN-INDUCED APOPTOSIS.
Submitted by sevy on Thu, 07/10/2008 - 10:25
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Dysregulation of normal apoptotic mechanisms provides a growth advantage to cancer cells [1]. In breast cancer, dysregulated apoptotic pathways include down-regulated death receptor pathway function, p53 mutations, and abnormal bcl-2 pathway function [2-4] Furthermore, breast cancer treatments including chemotherapy, radiation therapy and hormone therapy induce apoptotic mechanisms to cause cancer cell death [5]. Therefore, activation of specific apoptotic mechanisms in breast cancer cells could be an effective means to treat breast cancer.
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