Tear film is very important in the maintenance of an intact ocular surface and thus pathologies of the conjunctival and corneal epithelium are intimately related to tear film dysfunction. When tears are depleted various changes like squamous metaplasia, epithelial defects and infections of corneal epithelium can occur. It is with this objective in mind that ophthalmologists in the world over started searching for substances which could act as replacement for tears.
Artificial tears like hydroxypropyl methyl cellulose and carboxy methyl cellulose are effective in providing lubrication to the ocular surface, but are unable to substitute the nutrients and factors present in natural tears. Serum drops are non allergic and their biomechanical and biochemical properties are similar to normal tears.
Their use was first described by Fox et al (1) in 1984 in their search for a tear substitute free of potentially harmful preservatives. Later, Tsubota et al (2) reported that growth factors and vitamins present in serum eye drops have true epitheliotrophic potential for the ocular surface. Here we review the currently available literature on the use of this new approach.
Autologous Serum In Eye Disorders